Parallel Solution-Phase Synthesis and General Biological Activity of a Uridine Antibiotic Analog Library
نویسندگان
چکیده
منابع مشابه
Parallel Solution-Phase Synthesis and General Biological Activity of a Uridine Antibiotic Analog Library
A small library of ninety four uridine antibiotic analogs was synthesized, under the Pilot Scale Library (PSL) Program of the NIH Roadmap initiative, from amine 2 and carboxylic acids 33 and 77 in solution-phase fashion. Diverse aldehyde, sulfonyl chloride, and carboxylic acid reactant sets were condensed to 2, leading after acid-mediated hydrolysis, to the targeted compounds 3-32 in good yield...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2014
ISSN: 2156-8952,2156-8944
DOI: 10.1021/co4001452